Research Article
Novel Techniques in Epilepsy Management: Venous Pacing and Capture of Electrical Activity in the Primate Cortex
Author(s): Prakriti Gaba BS, Christopher V DeSimone, Benhur D Henz, Paul A Friedman, Charles J Bruce, David R. Holmes, Malini Madhavan, Krithika Vasudevan, Douglas Wahnschaffe, Steven Berhow, Andrew J Danielsen, Dorothy J Ladewig, Susan B Mikell, Susan B Johnson, Scott H Suddendorf, Tomas Kara, Gregory A Worrell and Samuel J AsirvathamPrakriti Gaba BS, Christopher V DeSimone, Benhur D Henz, Paul A Friedman, Charles J Bruce, David R. Holmes, Malini Madhavan, Krithika Vasudevan, Douglas Wahnschaffe, Steven Berhow, Andrew J Danielsen, Dorothy J Ladewig, Susan B Mikell, Susan B Johnson, Scott H Suddendorf, Tomas Kara, Gregory A Worrell and Samuel J Asirvatham
Objective: Pharmacotherapy for epilepsy is limited with 30% of patients’ refractory to this approach of suppressing seizures. Current surgical options are invasive and carry significant morbidities including infection, bleeding, and the potential for deleterious neurocognitive effects. As a result, there is a burgeoning need for innovation to develop safer and efficacious interventions.
Methods: Four distinct catheters (2 existing: Cardima catheter, Standard EPT Blazer catheter; 2 new prototypes: balloon catheter, basket catheters) were tested in 12 baboons (21-30 kg, 100% male). For each, we assessed whether or not the catheter was able to be maneuvered safely in various locations of the cerebral venous system, provide adequate cortical tissue contact to record signals, detect these signals as normal or abnormal, successfully stimulate t.. View More»
