Shweeta HA
Saudi Arabia
Research Article
Preparation and Bio-evaluation of 99mTc-carbonyl Complex of Ursodeoxycholic Acid for Heptobiliary Imaging
Author(s): Sanad MH and Shweeta HASanad MH and Shweeta HA
A method on the development of hepatobiliary imaging can be occurred by using 99mTc-tricarbonyl [99m Tc(CO)3(H2O)3]+ core with Ursodeoxycholic Acid (UDCA) under 30 min heating at 100ºC. Hepatobiliary imaging is also used to help diagnose symptoms such as: Abdominal pain that may be caused by a sudden inflammation of the gallbladder called cholecystitis, pain or fever following surgery on the gallbladder or the upper gastrointestinal tract. Biliary atresia in newborns, a blockage in the ducts that carry bile from the liver to the gall bladder. Labeling yield and stability were analyzed by high performance liquid chromatography (labeling yield>98% and stability for 6 h) at pH 9 and 3 mg substrate. RP-HPLC was used to evaluate the radiochemical yield and purity of the labeled product. Biodistribution studies were carried out in Albino Swiss mice at different time intervals after .. View More»
