Journal of Multiple Sclerosis

Biography

He is awarded PhD in Neurobiology  from Cambridge University, England in the year 2000. She holds a Bachelor of Medicine ,Southampton University.  Currently he is working as an Professor of Neurology, University of Edinburgh.

Research Interest

Professor Siddharthan Chandran works in the emerging discipline of Regenerative Neurology. His research combines laboratory activity that includes human stem cells with specialist clinics (multiple sclerosis [MS] and motor neurone disease [MND]) to both study disease as well as undertake early-phase clinical trials.

The ultimate aim is to develop novel regenerative therapies for neurodegenerative disease.

Clinical research, based at the Anne Rowling Regenerative Neurology Clinic, is founded on specialist clinics and linked disease registries to develop a clinical experimental infrastructure for longitudinal studies.

Current collaborative clinical projects include:

·         Epidemiological studies in MND (SMART-MND) and MS

·         MS-SMART - a major MRC-EME-funded clinical trial in secondary progressive MS

·         The Voice Bank initiative - using informatics to provide personalised synthetic voices for use in communication aids

·         Examining cognitive defects in MS using psychological testing paired with MRI brain scans

Lab research is focused on the glial-neuronal interaction in health and disease.

Current approaches include:

·         In vitro modelling of TDP43 proteinopathies using patient-derived iPS cells that have been converted into a range of functional neuronal and glial subtypes

In vivo modelling of the interactions between inflammation, neurodegeneration and repair in a mouse model of MS (Biozzi-EAE)

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