Solomon FD Paul
India
Research Article
Overexpression of Pro-Inflammatory Cytokines in Myelodysplastic Syndrome (MDS-RA)
Author(s): Natarajan Venkateswaran, Perumal Venkatachalam, Venkatesan Vettriselvi, Solomon FD Paul, Usha Nair, Margaret Chellaraj and Dominic F JosephNatarajan Venkateswaran, Perumal Venkatachalam, Venkatesan Vettriselvi, Solomon FD Paul, Usha Nair, Margaret Chellaraj and Dominic F Joseph
Background: Myelodysplasia comprises a heterogenous group of disorder characterized by ineffective hematopoiesis and extensive apoptosis of hematopoietic cells. Although previous studies revealed few cytogenetic and molecular abnormalities, the underlying defect in the molecular pathway for extensive apoptosis and dysplasia observed in the disease is yet to be identified. This study aims to evaluate the pro-inflammatory cytokines and transcription factors levels in the refractory anemia subset of myelodysplasia (MDS-RA). The study evaluated bone marrow aspirates from 35 MDS-RA and 10 leukemic cases. All samples were analyzed for the rate of apoptosis, levels of various pro-inflammatory cytokines such as TNF-α, TNF receptors, TGF-β, Fas, IFN-γ and transcription factor NFκB that moderates the apoptotic pathway, were estimated by quantitative PCR. Results: Increased a.. View More»
