Souhad El Akoum
Université de Montréal,
2900 boulevard Edouard-Montpetit, Montréal (QC) H3T 1J4
Canada
Review Article
PPAR Gamma at the Crossroads of Health and Disease: A Masterchef in Metabolic Homeostasis
Author(s): Souhad El AkoumSouhad El Akoum
The peroxisome proliferator-activated receptor gamma (PPAR?) is a ligand-activated transcription factor involved conferring the role of an active gland to the adipose tissue. This nuclear receptor is actively involved, mainly through its regulation to the physiology and the endocrine activity of the adipose tissue, in the regulation of a variety of processes governing the metabolic homeostasis. PPAR?, activated by a wide variety of fatty acids molecule or their metabolite, governs metabolic processes implicated in glucose and lipid metabolism and adipose mass control by modulating the expression of a large number of target genes. Furthermore, PPAR? is a molecular target for antidiabetic thiazolidinedione molecules that selectively bind this nuclear receptor to improve systemic insulin sensitivity and glucose tolerance. Accordingly, the specific position of PPAR? in systemic metabolic con.. View More»
