Stanislav Naryzhny
B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center “Kurchatov Institute”,
Orlova Roscha, Gatchina, Leningrad Region, 188300
Serbia
Research Article
Zipf's Law in Proteomics
Author(s): Stanislav Naryzhny, Maria Maynskova, Victor Zgoda and Ðlexander ArchakovStanislav Naryzhny, Maria Maynskova, Victor Zgoda and Аlexander Archakov
Human cells contain many thousands of protein components, protein species/proteoforms, whose cooperation provides the complicated functional mechanisms of the cellular proteome. Though recent methods still do not allow us to obtain the whole picture of this cooperation, they at least provide an opportunity to develop a representation of the proteome size and quantitative distribution of protein species inside the proteome. Using 2DE analysis followed by both protein staining and ESI LC-MS/MS analysis, we performed an analysis of the quantitative distribution of different protein species in human cells. We have analyzed several human cancer cell lines (HepG2, glioblastoma, MCF7) along with the primary liver cells from tissue samples and found that the dependence of the number of protein species on their abundance is described by Zipf’s law: y=ax-1 (1) Where y stands for the numbe.. View More»
DOI: 10.4172/jpb.1000427
