Takeshi Shimizu
Japan
Case Report
Lumbar-Peritoneal Shunt followed by Donepezil Administration for Residual
Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus: A Case
Report
Author(s): Shusuke Moriuchi, Makoto Dehara, Takeshi Shimizu, Shogo Fukuya, Takanori Fukunaga, Yasushi Hagihara and Takao SodaShusuke Moriuchi, Makoto Dehara, Takeshi Shimizu, Shogo Fukuya, Takanori Fukunaga, Yasushi Hagihara and Takao Soda
We often encounter idiopathic normal-pressure hydrocephalus (iNPH) and mild cognitive impairment (MCI) in the
same patient. Four iNPH patients whose gait improved following placement of a lumbar-peritoneal shunt (LPS) and
whose cognitive function improved after administration of donepezil are reported. LPS is useful for improvement of
gait disturbance in iNPH, and donepezil is used to treat impaired memory in dementia of Alzheimer’s type (DAT).
These four patients showed improvements in gait disturbances postoperatively, and just after donepezil
administration, improvements in cognitive symptoms were recognized in the memory tests of the Mini-Mental State
Examination (MMSE). The four patients (two males and two females) ranged in age from 72 to 81 years (mean age:
77 years). In all patients, disproportionately enlarged subarachnoi.. View More»
