Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Toktam Deylami
West Indies
Research Article
New Discernment of Pathophysiological Aspects of Multiple Sclerosis Based On Mono Amino Oxidase (MAO) and Ion Channel Receptor 5HT3RA as Activator of T-Cells
Author(s): Toktam Deylami, Mohammad Hossein Sanati and Ghasem AhangariToktam Deylami, Mohammad Hossein Sanati and Ghasem Ahangari
Background: Multiple sclerosis (MS) is a chronic, inflammatory and autoimmune disease of central nervous system. MS affects nearly 2.5 million people in the world and is twice more common in women than men. Autoimmune T-cells target the myelin sheath in central nervous system, causing inflammation, demyelination and eventual destruction of neurons. We examined changing expression of serotonin receptor (5-HT3RA) as well as monoamine oxidase (MAO-A) genes in peripheral blood mononuclear cells in MS patients.
Materials and methods: In this study, peripheral blood mononuclear cells (PBMC) were first isolated from 30 healthy controls and 30 volunteers with MS using Ficoll-hypaque. Total RNA was extracted and cDNA was synthesized. In this process, mRNA concentration of 5-HT3RA and MAO-A as target genes as .. View More»
