Virupaksha A Bastikar
India
Research Article
Screening and Identification of Structural Analogs of GW9662 and T0070907 Potent Antagonists of Peroxisome Proliferator-Activated Receptor Gamma: In-Silico Drug-Designing Approach
Author(s): Pramodkumar P Gupta, Shrinkhla Singh, Pritam Kumar Panda, Danish Ibrahim Jasnaik, Santosh S Chhajed and Virupaksha A BastikarPramodkumar P Gupta, Shrinkhla Singh, Pritam Kumar Panda, Danish Ibrahim Jasnaik, Santosh S Chhajed and Virupaksha A Bastikar
Peroxisome Proliferator-Activated Receptor Gamma encoded by PPARG gene is also known as type II nuclear receptor in humans plays a significant role in regulating the glucose metabolism, adipocyte differentiation and serves as a lipid sensor. This has been implicated in the pathology of various diseases like obesity, diabetes, atherosclerosis, and cancer. In search of drugs that uses PPAR gamma as a therapeutic target for its inhibition: Insilico CADD approaches has been widely used in this aspect to understand the intrinsic molecular aspects and their interaction with the chemicals. In-silico based virtual screening helps in identification of optimum molecule among the large dataset to elucidate the effects on a particular target through binding interaction and can be used for further experimentations. In the present study, two PPAR gamma/antagonists GW9662 and T0070907 were selected .. View More»
DOI: 10.4172/jpb.1000428
