Wangde Dai
HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes,
10 Pico Street, Pasadena, California 91105
Tanzania
Research Article
Effect of Diabetes on Myocardial Infarct and No Reflow Size in an Experimental Rat Model and Clinical Trial
Author(s): Wangde Dai, Robert A Kloner, Jianru Shi, Juan Carreno, Serge Korjian, Yazan Daaboul, Michael C Gibson, Muriel Bouly and Marc IsabelleWangde Dai, Robert A Kloner, Jianru Shi, Juan Carreno, Serge Korjian, Yazan Daaboul, Michael C Gibson, Muriel Bouly and Marc Isabelle
Background: We determined the effect of diabetes on no reflow and myocardial infarct sizes in both an experimental rat model of diabetes and a contemporary trial of subjects with STEMI.
Methods: Adult Zucker Diabetic Fatty (ZDF) and Sprague Dawley (SD) rats (n=15 each group) were subjected to left coronary artery occlusion for 30 min followed by 3 h of reperfusion. In the clinical trial, the myocardial infarct (MI) size and the zone of microvascular obstruction were assessed in 258 non-diabetic MI patient and 34 diabetic MI patients.
Results: There was no difference in infarct size (median) in ZDF rats (49.9%) versus SD rats (59.6%; p=0.32); there was no difference in no-reflow size (mean ± SEM) in ZDF rats (32.5 ± 3.5%) versus SD rats (32.7 ± 4.3%; p=0.97). In the clinical study, CK-MB and Tro.. View More»
