Wetzka B
Centre of Endocrinology and Reproductive Medicine Freiburg,
Bismarckallee, Freiburg
Germany
Research Article
An 1 h-OGLT is an Appropriate Approach for the Determination of Glucose and Insulin Dynamics in Female Functional Androgenization (Including “Polycystic Ovary Syndrome”)
Author(s): Wetzka B, Textor W and Geisthovel FWetzka B, Textor W and Geisthovel F
Female functional androgenization syndrome (FAS) is subdivided into 4 groups corresponding to their predominant organ pathology: I (ovary), II (adrenal gland), III (ovary, adipose tissue, liver, pancreas) and IV (residual dysfunctions). Group-specific variable clusters are defined by BMI, hormones, glucose and insulin during oral glucose loading test (OGLT: 0-, 1 h-, 2 h-values), and sonographic ovarian morphology. Abdominal circumference (AC), serum lipids, and blood pressure are used for individual characterization. We investigated which tests assess best the prevalence of pathologic glucose and insulin dynamics in androgenized women.
89 FAS patients were consecutively enrolled. Including a control (n=16), prevalence of insulin resistance (IR) described by OGLT, HOMA-IR, QUICKI, insulin sensitivity index (ISI) or AUC2h-insulin was analyzed. Uni- and multivariate correlation between .. View More»
