Xiaohui G
China
Case Report
Two Cases of Chronic Myelomonocytic Leukemia Combined with Monoclonal Gammopathy of Undetermined Significance and a Literature Review
Author(s): Fengling M, Lijia Z, Wei Z, Xiaohui G, Lina Z and Jianyong LFengling M, Lijia Z, Wei Z, Xiaohui G, Lina Z and Jianyong L
Objective: To describe myelodysplastic syndrome (MDS)/ myeloproliferative neoplasm (MPN) combined with monoclonal gammopathy of undetermined significance (MGUS) in order to investigate the potential association between these 2 diseases. Methods: Two cases of confirmed chronic myelomonocytic leukemia (CMML) combined with MGUS were reported here. In addition, reports related to cases with combined MDS or MPN with MGUS were reviewed. Results: The first case was a 77-year-old man whose routine blood tests showed abnormal hemogram results. The diagnosis was CMML combined with IgM monoclonal gammopathy, and the disease course was 4 years. The CMML gradually progressed, and the patient presented with anemia, thrombocytopenia, autoimmune hemolysis, and an increase in the number of immature cells in the bone marrow. Although the MGUS caused fluctuations in the concentrations of IgM, no IgM-ass.. View More»
