Xuan-Hong Tomai
University of Medicine and Pharmay,
Hochiminh city
Vietnam
Research Article
Evaluation of Trisomy 21 Screening by Fetal Nuchal Translucency Thickness, Maternal Age and Biochemical Serum in the South of Vietnam
Author(s): Xuan-Hong Tomai, Jean Pierre Schaaps and Jean Michel FoidartXuan-Hong Tomai, Jean Pierre Schaaps and Jean Michel Foidart
Aims: This study aimed to evaluate the most effective approach screening of trisomy 21 in the first trimester in Vietnam
Method: A prospective study carried out during 1 year. All pregnancies screened the risk of trisomy 21 by association of the fetal nuchal translucency, maternal age and biochemical serum (free β-hCG and PAPP-A) as a combined test in the first trimester. The amniocentesis was used to diagnose trisomy 21. In each 4 approaches screening (the isolated maternal age, the maternal age and fetal NT thickness, maternal age and biochemistry, and combined test), the detection rate and false positive rate of trisomy 21 were calculated to find out the most effective screening method.
Results: Followed up 2500 singleton pregnancies, the incidence of trisomy 21 was 0.6% (16/2500) (95%CI 0.4- 1.0%). The absence.. View More»
