Editorial Office, Journal of Internal Medicine, Belgium
Perspective
Myocardial Infarction, Macrophages Prevent an Electrical Storm by Stimulating Neutrophils
Author(s): Adam Hoffman*
In patients with coronary heart disease, sudden cardiac death, caused by aberrant electrical conduction, commonly happens. Arrhythmia and significant myocardial leukocyte alterations are brought on by myocardial ischemia at the same time. In this study, we improved a mouse model in which myocardial infarction and hypokalemia caused ambulatory animals to spontaneously develop ventricular tachycardia, and we demonstrated that major leukocyte subsets have opposing effects on cardiac conduction. In mice, neutrophils promoted ventricular tachycardia through lipocalin-2, but in patients, neutrophilia was linked to ventricular tachycardia. Macrophages, on the other hand, provide protection from arrhythmia. When Csf1 receptor blockade was used to reduce recruited macrophages in Ccr2/ mice or all macrophage subsets, it enhanced ventricular tachycardia and fibrillation. When evaluated in conjun.. View More»
DOI:
10.35248/1840-4529.22.14.7.374
