Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Department of Medicine, University of Florida, United States
Mini Review
A Novel Synthetic Peptide is Reviewed
Author(s): Adam Hoffman*
It is becoming more and clearer in neurology how important is neuroinflammation. Numerous non-inflammatory neurological conditions, including stroke, epilepsy, and cancer, as well as neuroinflammatory diseases like multiple sclerosis have been linked to neuroinflammation. The presence of CNS resident cells, mostly glial cells like microglia and the CNS resident macrophages is necessary for the immune response within the brain. To create a less hemolytic peptide with anti-neuroinflammatory, antibacterial, and cytotoxic effects against tumor cells, we examined the peptide Ca-MAP1, which was bioinspired on the immature cytolytic toxin of C. Albicans called candidalysin. Studies were carried out in vitro and silico at varying doses. Ca-MAP1 was not cytotoxic to MRC-5 and BV-2 cells and only displayed weak hemolytic activity at low concentrations. Acinetobacter baumannii, Escherichia coli .. View More»
DOI:
10.35248/2376-0389.22.9.07.453
