Journal of Multiple Sclerosis

Department of Medicine, University of Florida, United States

Publications

• Mini Review   
  A Potential Clinical Index for Parkinson's Disease Using Human Brain Magnetic Resonance Imaging
  Author(s): Adam Hoffman*
  
  Motor dysfunction brought on by substantia nigra functional decline is a hallmark of Parkinson's disease. In patients with Parkinson's disease, decreased putamen volume (also known as putamen atrophy) may be a significant clinical signal of motor dysfunction and neurological symptoms such autonomic dysfunction. On 31 highresolution T2-weighted magnetic resonance images from 19 healthy subjects (age: 75.1 7.85 years; eleven men, eight women) and 30 such pictures from 16 Parkinson's disease patients (age: 80.3 7.30 years), we devised and used a new evaluation approach for putamen volume quantification. An expression for putamen atrophy based on thalamic ratio was used. Using the Wilcoxon rank-sum test, the collected results were utilised to evaluate differences between the groups. The intraclass correlation coefficient demonstrated that this method's validity and intra-r.. View More»
  DOI: 10.35248/2376-0389.22.9.07.455

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