Journal of Multiple Sclerosis

Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany

Publications

• Mini Review   
  Leptin's Role in Obesity as a Dementia and Alzheimer's Disease Risk Factor
  Author(s): Adam Hoffman*
  
  Numerous people are affected by obesity, which is a widespread health issue caused by excessive ingestion of saturated fats, inactivity, or a sedentary lifestyle. Leptin is an adipokine that is released by adipose tissue and rises in obesity. It has central activities in the cerebral cortex, hippocampus, and other areas and nuclei of the Central Nervous System (CNS), in addition to the hypothalamus. These regions are the first to experience chronic neurocognitive deficits including mild cognitive impairment (MCI) and Alzheimer's disease because they express the long form of the leptin receptor LepRb, which is the only leptin receptor capable of conveying complete leptin signals (AD). As leptin resistance is usually linked to obesity, which is a chronic low-grade inflammatory condition, and obesity is thought to be a risk factor for AD, we examine various leptin resistance mechanis.. View More»
  DOI: 10.35248/2376 0389.22.9.11.475

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