Anatomical pathology Department, Anatomical pathology Department, Tunisia
Case Report
A Case of Chronic Lymphocytic Leukemia Revealed by an Obstructive
Jaundice
Author(s): Sarra Laabidi*, Amal Khsiba, Salwa Nechi, Houda Belfekih and Lamine Hamzaou
Chronic Lymphocytic Leukemia (CLL) is characterized by presence of abnormal monoclonal lymphocytes, circulating in blood that may infiltrate all organs, particularly those of lymphoreticular system. This disorder has a heterogeneous clinical course. Enlarged lymph nodes are the classical revealing manifestation. Gastrointestinal (GI) involvement in CLL, especially obstructive jaundice, is uncommonly reported, ranging from 5.7% to 13%. We report an isolated and unusual gastrointestinal involvement of CLL in an older patient. A 72-year-old man with Hepatitis C virus (HCV) infection presented an obstructive jaundice, revealing a Chronic Lymphocytic Leukemia (CLL) infiltration of hepatic hilar lymph nodes without another lymphadenopathy. CT-guided biopsy of lymph node mass confirmed neoplastic B-cell nature. Rituximab and Reduced Dose CHOP (R-miniCHOP) protocol, after plastic biliary sten.. View More»
DOI:
10.37532/occrs.22.8.(2).002