Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Koelliker Hospital, Turin, Italy
Case Report
Does the Coexistence of Tuberous Sclerosis and of Multiple Sclerosis in a Young Woman have a Common Pathogenic Mechanism?
Author(s): Nicolò Bruschi, Valeria Studer, Sergio Duca, Daniela Leotta and Antonio Bertolotto*
Tuberous Sclerosis Complex (TSC) is a genetic neurocutaneous disorder that presents with multi-organ involvement, including hamartomas in the brain, eyes, heart, lung, liver, kidney and skin. Multiple Sclerosis (MS) is a complex chronic inflammatory and neurodegenerative demyelinating disease of the Central Nervous System (CNS) of unknown etiology.
We report a 37-year-old woman with TSC who developed gradual tingling and hypoesthesia in her left hemi some. Magnetic resonance imaging (MRI) of the brain and cervical spine showed multiple cortical and subcortical tubers and sub ependymal nodules, along with diffuse and periventricular T2 white matter changes, and T2-STIR hyper intensity with edema at C3 level without gadolinium enhancement. Blood test was positive for multiple auto-antibodies not matching any specific autoimmune disease and lumbar puncture evidenced Oligo Clona.. View More»
DOI:
10.35248/2376-0389.23.10.06.501
