Department of Biomedical and Forensic Science, School of Human Sciences, University of Derby, Derby, DE22 1GB, United Kingdom
Research Article
Ionising Radiation Induces Autophagy in the Adult Drosophila Brain and Intestine.
Author(s): Bilal R Malik* and Terrence M Trinca
Exposure to various genotoxic and oxidative stresses can induce changes
in the internal state of a cell leading to cell death. Ionizing radiation is
routinely used in clinics to treat various types of cancers, with secondary
effects sometimes damaging internal organs particularly the gut. Drosophila
melanogaster has become one of the most trusted model organisms to study
human disease and various biological pathways. Here we have used gamma
radiation to determine for the first time whether they have an effect on
autophagy in two different tissues in Drosophila; the gut and the brain. We find
that in both tissues exposure to radiation leads to an increase in autophagy... View More»
DOI:
10.35248/2322-3308-11.2.005
