Editorial Office, Journal of Health and Medical Research, Belgium
Opinion
Adrenomedullin's Effects on Pulmonary Vein Arrhythmogenesis and Atrial Electrophysiology
Author(s): Elena Edward*
A new medication for the treatment of heart failure may be the peptide adrenomedullin, which has vasodilatory, natriuretic, and diuretic properties. Atrial Fibrillation (AF) is linked to a higher risk of heart failure, however it is yet unknown how adrenomedullin affects the development of atrial arrhythmia. This study looked into whether adrenomedullin affects the electrophysiology of the Pulmonary Vein (PV) or the atria. The effects of adrenomedullin (10 pg/mL, 30 pg/mL, and 100 pg/mL) on the electrical activity, mechanical responsiveness, and ionic currents of isolated rabbit PV and sinoatrial node tissue preparations as well as single PV cardiomyocytes were investigated using conventional microelectrode or whole-cell patch clamps. Adrenomedullin dramatically decreased the PVs' spontaneous beating rate from 2.0 Hz to 1.3 Hz and 1.1 Hz at concentrations of 30pg/mL and 100 pg/mL .. View More»
DOI:
1037532.jhmr.2022.4.6.129
