Journal of Multiple Sclerosis

Editorial Office, Journal of Multiple Sclerosis, Belgium

Publications

• Mini Review   
  Neurological Testing Following a Stroke in Nonhuman Primates and Models of Ischemic Stroke
  Author(s): Emma Reynolds*
  
  Rodents are more similar to humans than nonhuman primates in terms of genetics, neuroanatomy, physiology, and immunology. Therefore, nonhuman primates are regarded as the best preclinical model for simulating numerous elements of human stroke. Nonhuman primates' ischemic stroke models can better mimic the physiological signs and modifications that occur in people after cerebral ischemia. Stroke models in nonhuman monkeys have currently been constructed using a variety of techniques, including craniectomy models, endovascular stroke models, autologous thrombus models, and intraluminal filament models. In the meantime, fresh, novel approaches have been developed, including the photothrombosis and endothelin-1 models. These model studies have investigated numerous pathways that start in the first few minutes, hours, and days following a stroke throughout the past thirty years. In an .. View More»
  DOI: 10.35248/2376-0389.22.9.4.439

  Abstract HTML PDF