Department of Anatomy, Faculty of Medicine, JSSMC, Mysuru, India
Research
Centella asiatica leaves extract causes permanent changes in the dendritic architecture of Hippocampal CA3 neurons in albino mice
Author(s): Hemamalini and Muddanna S Rao
Introduction: Centella asiatica (CeA) is an herbaceous perennial creeper, growing in moist soil belonging to the umbelliferae family. Centella asiatica is used as brain tonic in ayurvedic medicine to enhance the neural function, learning and memory. This was correlated with improved dendritic arborization in normal animals. But CeA leaves extract protecting the neurons from neurodegeneration induced by stress was not reported. So in the present study the neuroprotective effect of CeA leaves extract on hippocampal CA3 neurons in restraint stressed mice was investigated first and then the effect of rehabilitation in stress and stress + CeA extract treated mice.
Materials and Methods: Experiment I: Three months old albino mice were divided into four groups. Group (i) was normal control, Group (ii) was saline control, Group (iii) was stress group, Group (iv) was stress + CeA treate.. View More»
