Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Department of Neuropsychiatry, Shebin Elkom Teaching Hospital, Menoufia, Egypt
Research
Homocysteine Serum Level as a Biomarker of Multiple Sclerosis Disability and Cognitive Impairment
Author(s): Rasha Hatem Ali, Ibrahim Abdel-Razik, Mohammed Salah ELsayed AlAhmar, Hesham Abdel-Shafy Dawood* and Khaled A Elkapany
Background: Multiple sclerosis (MS) is considered a progressive irreversible disease that makes neurological dysfunction. Homocysteine is a biomarker that is linked to physical disability and cognitive impairment in patients with MS.
Objective: To study the prevalence of hyperhomocysteinemia in MS patients. To study the possible association between hyperhomocysteinemia (HHcy) and physical disability, and cognitive impairment in MS patients. Patients and Methods: This was a case-control study that was carried out on 40 MS patients, and 40 controls comparable in age, sex, and socioeconomic status. Patients underwent Cognitive, physical, and laboratory assessments including homocysteine serum level.
Results: Homocysteine serum level was significantly higher in the cases group than in the control group. HHcy is associated with cognitive impairment in MS patients. Physical di.. View More»
DOI:
10.35248/2376-0389.23.10.1.481
