Journal of Multiple Sclerosis

Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, USA

Publications

• Research Article   
  A Clinical Perspective: Somatosensory Evoked Potentials May Suggest MS Type and Care Management
  Author(s): George H Kraft, Katie T Singsank*, Sarah B Simmons and James D Bowen
  
  Background: This Multiple Sclerosis (MS) is a Central Nervous System (CNS) disease characterized by demyelination or axonal loss encompassing several clinical subtypes—Relapsing-Remitting MS (RRMS), Secondary-Progressive MS (SPMS), and Primary-Progressive MS (PPMS). Strategies for treating progressive forms are limited, and better understanding of underlying pathophysiology is essential. Method: Somatosensory Evoked Potentials (SEP) were analyzed for CNS conduction slowing caused by myelin impairment defined as 3 or more standard deviations, in 109 people with MS (16 with PPMS compared to 93 with RRMS and/or SPMS). Results: People with RRMS and SPMS have a higher prevalence of CNS conduction slowing compared to PPMS (83.9% compared to 12.5% respectively, P<.001). Subgroup analysis suggests this is not due .. View More»
  DOI: 10.35248/2376-0389.21.8.241

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