Editorial Office, Plastic Surgery: Case Studies, Belgium
Short Communication
The Significance of Renin-Angiotensin System in Keloid Disarray
Author(s): Jason Mazow*
The fibro proliferative disease Keloid Disorder (KD) is characterized by excessive dermal collagen deposition in response to skin injury and/or inflammation. Treatment for KD remains empirical and unsatisfactory despite much study. Through its direct influence and the resulting hypertension, activation of the Renin-Angiotensin System (RAS) causes fibrosis in many organs as well as immune system activation. The greater frequency of KD among dark-skinned people who are prone to vitamin D deficiency (VDD) and hypertension, as well as the link between KD and hypertension and VDD, both of which are linked to increased RAS activity, shed light on the etiology of KD. Embryonic-like Stem (ESC) cells that exhibit ESC markers inside Keloid-Associated Lymphoid Tissues (KALTs) are increasingly being linked to keloid lesions. The RAS, catharsis B, D, and G, which form RAS bypass loops, and the Vit.. View More»
DOI:
10.37532/pscs.22.3.1.1-2
