Department of Neurosurgery, Manmohan Memorial Medical College and Teaching Hospital, Swoyambhu, Kathmandu, Nepal
Case Series
Dabigatran, A Direct Thrombin Inhibitor (DTI) as the First Line Treatment for Cerebral Venous Thrombosis. An Updated Case Series
Author(s): Abhishek Chaturbedi* and Jitendra Thakur
Background: Cerebral venous sinus thrombosis (CVST) is a rare form of stroke
which still carries significant morbidity and mortality. Previous treatment
regimen pertained to primarily medical therapies, with use of anticoagulants
like Coumadin and Heparin. However the advent of Direct Thrombin Inhibitors
(DTI) which do not need regular monitoring of blood coagulation panel and
has better safety profile than Coumadin, has been suggested as a treatment
modality for CVST in recent literature.
Case Description: It is a case series of 7 adult patients presenting with
intracerebral hemorrhage secondary to CVST from occlusion of dural venous
sinuses. Dabigatran, a DTI was used as the primary treatment modality for
a period of 6 months for 5 patients who had identifiable underlying cause
and lifelong for 2 patient who had.. View More»
