Shandong Qianfo Mountain Hospital, Jinan, Shandong, China
Research
Effect of TGN-020 on Learning and Memory in 8-Month-Old APP/PS1 (AD) Mice
Author(s): Mengzhen Zhou, Yaran Li and JiYou Tang*
Background: Decreased AQP 4 expression causes decreased circulatory function of the glymphatic system, and abnormal deposition of proteins such as A β 42 and Tau in the brain. The loss of AQP 4 may be a risk factor for Alzheimer's disease.
Objective: To explore whether TGN-020 (AQP 4 blocker) damages learning and memory, aggravates A β deposition, and whether the combination of DORA and TGN rescues learning and memory impairment in mice.
Methods: During the 28-day intervention period, APP/PS1 mice (AD model mice) received drugs by intraperitoneal injection daily at the start of the light phase (6:00 am). Mouse learning and memory were assessed by the Y and Morris water mazes. After analysis of behavioral parameters, Aβ deposition in the mouse brain was evaluated by immunohistochemistry.
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DOI:
10.35248/2332-2594.23.14 (7).341
