Editorial Office, Journal of Internal Medicine, Belgium
Opinion
A Versatile Protein Scaffold for Biotherapeutics is Ferritin
Author(s): Lisa Edward*
In almost all animals, there is an endogenous protein called the ferritin nanocage. The hollow spherical structure's capacity to naturally store iron ions has been used in a variety of bio-therapeutic research projects. The nanosized ferritin particles show controlled/sustained release pharmacokinetics and have outstanding biosafety characteristics. Additionally, the huge surface-to-volume ratio and the behaviour of the 24 monomer subunits breaking down and reassembling into a sphere allow for a variety of chemical and genetic alterations on the ferritin surface and inner cage. Here, we offer a critical analysis of ferritin and its uses. We offer an (i) overview of the use of ferritin in imaging and diagnosis for biomedical reasons, (ii) explore ferritin-based vaccinations, and (iii) examine ferritin-based agents now in clinical trials. We also introduce the application of ferritin in dr.. View More»
DOI:
10.35248/1840-4529.22.14.9.385
