Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland
Research Article
Is there an association between pulmonary metastases and Wilms tumor histopathology
Author(s): Seppo Taskinen*, Outi Leskinen, Minna Koskenvuo, Jouko Lohi and Mervi Taskinen
Purpose. To evaluate if Wilms tumor histopathology predicts occurrence of pulmonary metastases and the response of lung metastases to neoadjuvant chemotherapy. Methods. Seventy-nine patients under age 16 years were identified with Wilms tumor in 1988 – 2015. All thoracic CT-images before and after neoadjuvant chemotherapy with suspected metastases were re-evaluated. Tumor volumes were measured from CT- or MRI-images (available in 52/79 patients). Tumor samples from both pre-treatment cutting needle biopsies (CNB) and from nephrectomy were re-evaluated (59/79). Results. Pulmonary metastases were found in 14 out of 79 (18%) patients. Patients with pulmonary metastases had larger Wilms tumor volume (903, IQR 807-1215 ml vs. 428, IQR 299-765 ml; p<0.001), and tended to have predominance of blastemal cells in diagnostic CNB (75, QR 50-97% vs. 50, IQR 20-80%; p=0.064) compared to t.. View More»
