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Medical Reports & Case Studies

ISSN - 2572-5130

Nikolaos Tzenios

Prof, Public Health and Medical Research, Charisma University, Grace Bay, Turks and Caicos Islands. Doctor of Health Sciences Candidate, MCPHS University, Boston, Massachusetts, USA

Publications

  • Research Article   
    Variable vs. Fixed Dosing of Monoclonal Antibodies in Oncology
    Author(s): Nikolaos Tzenios*, Mary E. Tazanios and Mohamed Chahine

    Oncological patients need the proper doses of medications to facilitate their recovery. The two basic approaches used in dosing Monoclonal Antibodies (mAbs) are fixed-dose combination and variable dosing. In Fixed-Dose Combination Drugs (FDCs), two or more active components are combined in a single formulation at a predetermined dose. Variable dosage, which has long been the industry standard, is the polar opposite of this approach. The body changes over time; the Body Surface Area (BSA) in square meters is often used as a Measure (m2). This study uses a systematic review. Most mAbs used in oncology are predominantly given as cytotoxic anticancer drugs using body-size-based (variable) regimens. Despite the benefits of fixed-dose, variable dosing has become the industry standard, despite being criticized for ineffectiveness. While variable dosing has some advantages, the prevalent view.. View More»
    DOI: 10.4172/2572 5130.22.7(10).1000218

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