Editorial office, European Journal of Clinical Oncology, UK
Case Report
Injury and kidney cancer
Author(s): Noah Scott*
Epidemiologic research shows a strong link between acute or chronic kidney injury and kidney tumors. However, it is unclear whether these associations are causally linked and in which direction. Data from basic and clinical research are now shedding light on this issue, prompting us to propose a new pathophysiological concept with immediate implications for the management of patients with kidney disease and kidney tumors. As a central paradigm, this review proposes kidney damage and repair mechanisms that are active not only during acute kidney injury but also during chronic kidney disease as triggers of DNA damage, promoting the expansion of (pre-) malignant cell clones. We discuss how the different types of kidney tumors relate to renal progenitors at specific sites of injury and to germline or somatic mutations in distinct signaling pathways, as renal progenitors have been identifi.. View More»
DOI:
10.35248/clinical-oncology. 4(5).61-62
