Department of Internal Medicine, Hospital Angeles Clinica Londres, North America, Mexico
Mini Review
Antibody Miopathy Associated with AntiHydroximethylglutaryl Coenzyme: A Reductase in a Simvastatin User
Author(s): Maria de los Angeles Chavez Corona*, Barbara Perez-Aguilar, Raul Valencia Lopez, Daniel R Hernandez Salcedo and Sara Isais Millan
Autoimmune myopathies result from direct or indirect injury to muscle fibers mediated by the immune
system. The term myositis is generally interchangeable with “Idiopathic Inflammatory Myopathy”,
which refers to primary autoimmune muscle diseases. These include dermatomyositis, inclusion body
myositis, antisynthetase syndrome, and Immune Mediated Necrotizing Myopathy (IMNM). Other
known causes of inflammatory myopathies include infections, drugs, mixed connective tissue diseases
and cancer. In 2017, the European neuromuscular centre described two subtypes of IMNM, each
mediated by a different antibody: Anti-SRP and Anti-3-Hydroxy-3-Methyl Glutaryl Coenzyme A
reductase (Anti-HMG-CoA), each presents with a different clinical and histopathological course. The
first is associated with a more aggressive disease and a low response to conventional immunoth.. View More»
