Department of Pharmacology, School of Pharmaceutical Sciences, CT University, Ludhiana, India
Review Article
Insight on Poly (ADP-Ribose) Polymerase (PARP) as a Potential Pharmacological Target in Pathological Conditions
Author(s): Mandeep Kaur and Saurabh Sharma*
Recent studies have clearly indicated that Poly (ADP-Ribose)
Polymerase (PARP) has an essential role in various physiological and
pathophysiological pathways including the signaling of DNA damage, cell
death pathways, cell survival and proliferation pathways, differentiation,
neuronal function and inflammation. Role of PARP has been established
in cardiovascular diseases like myocardial infarction, endothelial
dysfunction associated hypertension, ischemia-reperfusion injury. It also
plays an important role in the pathophysiology of diabetes, inflammatory
disorders, and various neurodegenerative disorders. Approaches in this
area lead to the identification of 18 putative PARP sequences in the
human genome. PARP-1 is a most abundantly found nuclear protein which
functions to sense the DNA damage. Increased oxidative stress due to
any pathophysiological c.. View More»
DOI:
10.35248/2322-3308.21.10.008
