Department of Medical Oncology, Grampians Health, Ballarat, VIC, Australia
Case Report
DOTATATE PET-avid Clear Cell Stromal Tumour of the Lung with YAP1::TFE3 Fusion: Report of First Australian Case
Author(s): Scarlett Yao, Sharon Wallace, Catherine Mitchell, Naomi Frederick, Christopher R McEvoy, David Choong and Wasek Faisal*
Clear Cell Stromal Tumour of the Lung (CCST-L) is a recently recognised rare lung neoplasm, with only 19 cases reported in the current literature. Its histogenesis and pathogenesis remain largely unknown, however recent studies demonstrated the recurrent finding of YAP1::TFE3 fusion, highlighting its likely contribution to the pathogenesis. Currently, the diagnosis of CCST-L is confirmed with histological findings, exclusion of lineage-specific differentiation on immunohistochemical staining and molecular testing. With previous reports of progressive disease and mortality from distant metastasis, CCST-L posts the potential of rapid progression. Currently, no general consensus has been reached for the implication of neoadjuvant or adjuvant chemotherapy in CCST-L. Its rarity also presents the difficulty in obtaining long-term follow-up and prognostication data. We herein present the fir.. View More»