Oncology consultant at King Abdulaziz University Hospital, Jeddah, Saudi Arabia
Research Article
The Relation between Estrogen-positive Receptor in Breast Cancer (ER+) and Obesity in Jeddah
Author(s): Sabah Abdulaziz Linjawi*, Sarah Abdullah Hifni and Shadi Salem ALKhayyat
Breast cancer is one of most common malignancy among women. About 74% of breast cancers have classified as estrogen receptor positive (ER+) breast cancer. As obesity play a role in altering estradiol hormone level, it is important to focus on obesity as one of ER+ breast cancer risk factor. The aim of this research was; to investigate the distribution of ESR1 gene alleles, comparing estradiol level between breast cancer patients and control group (obese and normal), and to correlate this single nucleotide polymorphisms (SNP) to obesity in ER+ breast cancer patient. The study included 119 participants (59 controls, 60 ER+ breast cancer patients). Two blood samples were collected from each participant; one were for studying the distribution of polymorphism in intron 3 in ESR1 (rs2347867 G>A+27944) using Restriction Fragment Length Polymorphism .. View More»
