Department of Biotechnology, Amity University, India
Commentary
Multi-scale Image Analysis and Prediction of Visual Field Defects after Selective Amygdalohippocampectomy
Author(s): Shagufta Hasan*
Patients with therapy-refractory temporal lobe epilepsy benefit from selective amygdalohippocampectomy, however it can induce Visual Field Defects (VFD). We used whole-brain studies from voxel to network level to describe tissue-specific pre- and postoperative imaging correlates of VFD severity. Pre- and postoperative MRI (T1-MPRAGE and Diffusion Tensor Imaging) as well as kinetic perimetry according to the Goldmann standard were performed on 28 individuals with temporal lobe epilepsy. Using voxel-based morphometry and tract-based spatial statistics, we looked for whole-brain Grey Matter (GM) and White Matter (WM) correlations with VFD. We also performed local and global network studies, as well as reconstructing individual structural connectomes. The postsurgical GM volume decreased with increasing VFD severity in two clusters in the bihemispheric middle temporal gyri (FWE-corrected .. View More»
DOI:
10.35248/1840-4529.22.14.377
