Journal of Multiple Sclerosis

Department of Neuroscience, Central Clinical School, Monash University, Australia

Publications

• Mini Article   
  Are Dilated Virchow Robin Spaces a Generalized Marker of Disease in Multiple Sclerosis?
  Author(s): Jacob Miles, Ariana Simps* and Simon Keller
  
  Virchow Robin Spaces (VRS), perivascular spaces surrounding cerebral blood vessels, facilitate fluid exchange between blood, cerebrospinal fluid, and interstitium. Enlarged VRS are common in both health and disease, with evidence suggesting associations with cardiovascular risk factors. However, their contribution to disease pathogenesis remains unclear. Limited evidence links enlarged VRS to clinical measures of disease severity across various neurological conditions. In Multiple Sclerosis (MS), while some studies suggest associations with lesion volume and disease severity, a meta-analysis failed to replicate these findings, indicating the limited utility of VRS as diagnostic or prognostic markers. Methodological limitations in VRS identification and quantification challenge the strength of these associations. Future research should focus on refined quantification methods .. View More»
  

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