Editorial office, European Journal of Clinical Oncology, Finland
Commentary
The expression of IL-36 is elevated in NSCLC, and lung cancer
Author(s): Syria Watson*
Asthma and COPD are two respiratory disorders that have been linked to the IL-36 cytokines, a recently identified subset of the IL-1 family of cytokines. The purpose of this study was to look at the role of IL-36 cytokines in the pathogenesis of lung cancer in light of the shared aetiological ties between COPD and the emergence of lung cancer as well as the involvement of other IL-1 family members in the development of lung tumors. In this study, we show that lung cancer tissue expresses considerably higher levels of IL-36 cytokines and receptor mRNA and protein than does nearby non-tumor tissue. Two lung cancer cell lines, LLC murine lung cancer and SKMES-1 human squamous cell, were stimulated in in vitro tests. In all lung cancer cell lines, all IL-36 cytokines increased the expression of pro-inflammatory chemokines, and when cells were stimulated with IL-17, IL-22, and TNF, synergi.. View More»
DOI:
10.35248/clinical-oncology.23.5(2).1
