Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa
Research Article
Effect of Bromelain on BDNF level and memory deficit following intra-medial forebrain bundle 6-OHDA injection in rat model of Parkinsonism
Author(s): Temitope Samson Adu* and Musa Vuyisile Mabandla
Introduction: Episodic memory is a complex cognitive process that allows the encoding, storage and retrieval of unique events associated with the context in which they occurred. The memory function is however affected in Parkinson’s disease (PD) and this is quite associated with the functional loss of brain derived neurotrophic factor (BDNF) which is highly expressed within the brain. This study therefore addressed the question of whether prior/post bromelain treatment was able to show an effect on the memory function and BDNF level in 6-OHDA injected rat model of Parkinsonism. Methods: Male Sprague-Dawley rats were injected stereotaxically with the neurotoxin 6- OHDA. The anti-inflammatory agent, bromelain (40 mg/kg i.p) was used to treat a subset of the rats prior to or 24 hr post 6-OHDA lesion. Discrimination index in the neurotoxin injected rats was assessed using the novel .. View More»
DOI:
10.35248/2155-9562.20.11.504
