Department of Pharmacy, Noida Institute of Technical Engenieering, Greater Noida, India
Short Communication
Natural Killer Cells in Adoptive Cell Immunotherapy for Cancer
Author(s): Vikas Yadav* and Deepanshu Kumar
Natural Killer (NK) cells are a distinct subpopulation of innate lymphoid cells with the innate capacity to recognise and destroy cancerous and virally-infected cells. NK cells play a crucial role in anticancer immunity due to their various cytotoxicity mechanisms and capacity to modify the immune response through cytokine production. When NK cells were utilised as immunotherapeutic agents and demonstrated safety and efficacy in the treatment of patients with advanced-stage leukaemia, this role was made clear almost two decades ago. Following the groundbreaking achievements of CAR-engineered adoptive T cell treatment and the development of technologies that can transform cells into potent antitumor weapons, interest in NK cells as a potential immunotherapy option has surged tremendously in recent years. Strategies for the development of NK cell-based therapies emphasise co-stimulatory.. View More»
DOI:
10.35248/1840-4529.22.14.10.389
