Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
College of Physical Education, Chaohu University Anhui Province, China
Research Article
Exercise Training Alleviates Cognitive Functions in Diabetic Rats through the Hmgb1/Rage/Nf-?b Pathway
Author(s): Wang Yan and Wang Chengji*
Objective: To observe the effect of exercise training on cognitive functions of a diabetic rat model.
Methods: Male SD rats were given a high fat and high sugar diet, except for the control group. Afte rfour weeks, 35 mg /kg STZ has intraperitoneally injected to establish type 2 diabetes model rats. After successful modelling, rats were randomly divided into the model group, model + exercise group. Animals performed five days of consecutive treadmill exercise (60 min/day) with 22 m/min speeds for 60 days. After 60 days, Morris water maze task was used in the behavior test. Then rats were weighed, and blood samples were obtained to detect blood glucose. Some animals are sacrificed to prepare serum to detect glycosylated hemoglobin. Brain tissues were taken to detect the protein expressions of HMGB1-/RAGE-/NF-κB signal pathway. The brain.. View More»
DOI:
10.35248/2376-0389.23.10.05.497
