Department of Pediatric Cardiology, Children’s Hospital of Anhui Medical University, Anhui, China
Research Article
Serum Amyloid A as a Biomarker of Immunoglobulin Resistance in Kawasaki Disease
Author(s): Xiaobi Huang, Sheng Zhao, Zhiyuan Liu, Yanyan Xu and Fang Deng*
Background: Intravenous Immunoglobulin (IVIG) resistance prediction is a main topic of interest in Kawasaki disease (KD). In this study, we examined the value of Serum Amyloid A (SAA) for predicting IVIG resistance in KD patients.
Methods: 409 KD patients were retrospectively enrolled and divided into IVIG responsive (n=366) and IVIG resistant (n=43) groups according to the definition of IVIG resistance. Serum SAA levels prior to IVIG therapy were measured at the acute phase. Demographic, echocardiography, and laboratory data were also retrospectively analyzed.
Results: Levels of SAA, total bilirubin, C-reactive protein, neutrophils, alanine aminotransferase, aspartate aminotransferase, interleukin-6 and procalcitonin were significantly higher in the IVIG resistant group than in the IVIG responsive group (P<0.05), .. View More»
DOI:
10.35248/2322-3308-23.12.3.002
