Journal of Multiple Sclerosis

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Publications

• Research   
  Pleiotropic Genetic Effects between Multiple Sclerosis and Musculoskeletal Traits
  Author(s): Sohyun Ju Tsai, Ming Jeong, Changbing Shen and Yi-Hsiang Hsu*
  
  Background: Musculoskeletal disorders were commonly reported in patients with multiple sclerosis. However, the underlying etiology linking Multiple Sclerosis (MS) and musculoskeletal disorders is not well studied. With large-scale Genome-Wide Association Studies (GWAS) publicly available, we conducted genetic correlation analysis to identify shared pleiotropic genetic effects between MS and musculoskeletal traits. We also conducted Mendelian Randomization (MR) to estimate the causal relationship between MS and increased risks of musculoskeletal disorders. Methods: Linkage Disequilibrium Score Regression (LDSR) analysis was performed to estimate heritability and genetic correlation. Univariable, multivariable, and bidirectional MR analyses were conducted to estimate the causal relation. These analyses were done by utilizing the recent GWAS summary statistics of MS, fracture, .. View More»
  DOI: 10.35248/2376-0389.23.10.4.494

  Abstract HTML PDF