Neurology and Neurorehabilitation

Neurogenesis in adult humans remains a controversial area of research among neuroscientists. Methodological challenges have hampered investigators from conducting high-quality, in-vivo studies that can help elucidate the presence and/or activity of neurogenesis in human brains. Additionally, the studies that have been done in humans report conflicting results, further adding to the ambiguity surrounding the concept of adult neurogenesis in humans. In this review article, the authors seek to help clarify the concept of adult neurogenesis by providing an overview of the basic concept, as we currently understand it, including its historical birth and evolution. Some researchers theorize that the SGZ is a conducive environment for the proliferation of NSCs into granule Innovations in Clinical Neuroscience. The concept of neurogenesis in adult humans is a controversial topic among researchers in the field of neuroscience. While some researchers report that a sharp drop in neurogenesis occurs as the human brain ages, other researchers report that neurogenesis in the dentate gyrus (DG) of the hippocampus of human brains persists into old age. A clearer understanding of the evidence surrounding the concept of adult human neurogenesis is important because its presence or absence can affect the foundations on which our concepts of the mechanisms of learning and memory are built, particularly with reference to aging, and the pathogenesis and management of many neuropsychiatric disorders. If neurogenesis in the adult hippocampus is not present, then other concepts of neuroplasticity, such as changes in synaptic transmission or remodeling of existing neurons, might move to the forefront of theory with respect to brain activity and dysfunction. In this review, we describe the basic concept, as well as provide a historical overview, of neurogenesis. We also critically analyze the current state of research on neurogenesis in adult humans and evaluate how the concept of neurogenesis has impacted current treatment of neuropsychiatric disorders. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal. Journal with higher impact factor is considered to be more important than other ones.