Biopharmaceuticals are the chemical entities that are used as medical drugs in the treatment of illness which are produced by using biotechnological techniques. The biopharmaceuticals basically includes the macro-molecular products like proteins, nucleic acids, etc. which are employed as protein-based (like antibodies) and or nucleic acid-based (like antisense-oligonucleotide) drugs. The microorganisms like viruses and bacteria can also be used as biopharmaceutical therapeutics and or finds its application as in vivo diagnostic purposes. This subset of biopharmaceuticals including attenuated microorganisms and or the medical products composed of cellular or tissue based matter is generally referred as biologics for example stored RBC units. The attenuated microorganisms whose virulence has been reduced are produced by means other than the direct extraction from their native biological sources as using non-engineered biological sources may pose the higher risks in its usage. The first biopharmaceutical substance produced and approved for therapeutic use was insulin via recombinant DNA technology. A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.