The traditional applications of biotechnology/bioprocessing are mostly in the area of food, bakery products, alcoholic beverage, which are still important up to this date. The commercial success of production of the penicillin lead to the ideal and contamination-free environment bioprocessing and the advance to genetic engineering of microbial, animal and plant cells to produce recombinant proteins or metabolites. Vistas in recombinant DNA techniques, gene manipulation, cell fusion and tissue culture make micro batch reactors no longer hindrance. However, the scale-up technique to translate a scientific invention into commercial reality is not that easy as yet due to the complexity of biological systems and hardship in control. If utilization of mathematical modeling of the rate of cell growth, product formation and substrate uptake, and vigorous evaluations and monitoring of various process parameters in aseptic environmental conditions may bring pilot-scale step may be completed successfully, then the industrial-scale operations commences. This aim of this presentation is to enlighten biotechnologists with some engineering disciplines and to enable the communication on a professional level with bioprocess engineers in both upstream and downstream technologies within the given presentation time. In upstream technology, different reactors (batch reactor, continuous reactors, fed-batch/semi-batch reactors, fluidized bed reactor, immobilized cell bioreactors, airlift reactor), media design, and mixing will be elucidated. In downstream processing operations (also known as unit operations) involve using adsorption, centrifugation, chromatography, crystallization, drying, evaporation, filtration, flocculation, homogenization, microfiltration, milling, precipitation, sedimentation, solvent extraction and ultrafiltration for cell removal, cell disruption, cell debris removal, primary isolation, product enrichment and final isolation and treatment of effluents. Worldwide backings this framework and gives access to 700+ companion inspected diaries without any limitations and in this way advances the Open Access development so as to advance logical progression. The advanced companion looked into diaries spread the novel and ebb and flow logical investigations occurring across colleges and examination focuses in different pieces of the world. Each open access diary conveys the most recent updates in the regarded research territory in different arrangements with the goal that endorsers can get to the equivalent through different alternatives. With the developing number of logical lovers and perusers by an enormous edge, the adequacy of open access distributing has seen a self-assured effect.
