Hemostasis occurs when blood is present outside of the body or blood vessels. It is the innate response for the body to prevent bleeding and loss of blood. During hemostasis three steps occur during a rapid sequence. Vascular spasm is that the first response because the blood vessels constrict to permit less blood to be lost. In the second step, platelet plug formation, platelets stay together to make a short-lived seal hide the break within the vessel wall. The third and last step is named coagulation or blood coagulation. Coagulation reinforces the platelet plug with fibrin threads that act as a "molecular glue". Platelets are an outsized think about the hemostatic process. They allow for the creation of the "platelet plug" that forms almost directly after a vessel has been ruptured. Within seconds of a blood vessel's epithelial wall being disrupted, platelets begin to adhere to the sub-endothelium surface. It takes approximately sixty seconds until the primary fibrin strands begin to intersperse among the wound. After several minutes the platelet plug is totally formed by fibrin.
