Serum levels of liver enzymes, such as alanine transaminase, aspartate transaminase, and α-fetoprotein, provide insight into liver function and are utilized during treatment of liver disease, but such information is circumscribed. In the case of hepatocellular carcinoma (HCC), which is often not detected until an advanced stage, more sensitive biomarkers may avail to achieve earlier detection. Serum additionally contains microRNAs, a class of minuscule non-coding RNAs that play a consequential role in regulating gene expression. This is the first European joint effort by the European Sodality for the Study of the Liver (EASL) and the European Organization for Research and Treatment of Cancer (EORTC) to provide prevalent guidelines for the management of hepatocellular carcinoma. To increase the visibility and ease of use of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving services. Indexing provides easy access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles, editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly.