Mumps is a viral disease caused by mumps
virus that affects the parotid glands which causes the cheeks to puff out. Symptoms include swollen, painful salivary glands on one or both sides of your face (parotitis), Fever, Loss of appetite,
Pain while chewing or swallowing. Mumps is caused by the mumps
virus (MuV), a member of the Paramyxoviridae family of enveloped, non-segmented, negative-sense RNA viruses. Mumps is characterized by painful inflammatory symptoms, such as parotitis and orchitis. The
virus is highly neurotropic, with laboratory evidence of central nervous system (CNS)
infection in approximately half of cases. Symptomatic CNS
infection occurs less frequently; nonetheless, prior to the introduction of routine vaccination, MuV was a leading cause of aseptic
meningitis and viral encephalitis in many developed countries. Despite being one of the oldest recognized diseases, with a worldwide distribution, surprisingly little attention has been given to its study. Cases of aseptic
meningitis associated with some vaccine strains and a global resurgence of cases, including in highly vaccinated populations, has renewed interest in the virus, particularly in its
pathogenesis and the need for development of clinically relevant models of disease. In this review we summarize the current state of knowledge on the virus, its
pathogenesis and its clinical and pathological outcomes. Before routine mumps
vaccination programmes were introduced, 95% of adults had serological markers of exposure, with peak acquisition during childhood
Relevant Topics in Medical Sciences